Thieno [3,2-d] pyrimidin-4-one Derivatives as Potential Antibacterial Agents
نویسندگان
چکیده
Several thieno [3,2-d]pyrimidin-4-ones (4a-i) were conveniently prepared by the thio-claisen rearrangement of 5-prop-2-ynylsulfanyl pyrimidin-4-ones derivatives. The constitution of the products was supported by IR, PMR and mass spectral study. The compounds synthesized were tested in vitro against gram positive microorganisms, Bacillus subtilis, Bacillus cereus, Staphlococus aureus, Enterococcus faecalis and gram negative microorganism Eseherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, Klabsiella pneumoniae and Shigella sonnei. Standard drugs were also tested under identical conditions for comparing the results.
منابع مشابه
Simple approach to thieno[3,2-d]pyrimidines as new scaffolds of antimicrobial activities.
6'-(4-Chlorophenyl)-spiro[cyclohexane-1,2'-thieno[3,2-d][1,3] oxazin]-4'(1'H)-one (1) was synthesized and used as a starting material for the synthesis of a novel series of spiro compounds having biologically active sulfonamide 2a-e and 3'-(4-acetylphenyl)-6'- (4-chlorophenyl)-1'H-spiro[cyclohexane-1,2'-thieno[3,2-d] pyrimidine-4'(3'H)-one (3). Compound 2a was used as a key intermediate for the...
متن کاملEfficient synthesis of 4-aminoquinazoline and thieno[3,2-d]pyrimidin-4-ylamine derivatives by microwave irradiation.
[reaction: see text] A simple, efficient, and high-yielding synthesis of quinazolin-4-ylamine and thieno[3,2-d]pyrimidin-4-ylamine derivatives is reported under microwave irradiation conditions. Reaction conditions including temperature, solvent, and reaction time have been studied. An efficient parallel workup procedure was developed to generate a small library (23 compounds) in a short time p...
متن کاملNew potential antitumoral fluorescent tetracyclic thieno[3,2-b]pyridine derivatives: interaction with DNA and nanosized liposomes
Fluorescence properties of two new potential antitumoral tetracyclic thieno[3,2-b]pyridine derivatives were studied in solution and in liposomes of DPPC (dipalmitoyl phosphatidylcholine), egg lecithin (phosphatidylcholine from egg yolk; Egg-PC) and DODAB (dioctadecyldimethylammonium bromide). Compound 1, pyrido[2',3':3,2]thieno[4,5-d]pyrido[1,2-a]pyrimidin-6-one, exhibits reasonably high fluore...
متن کاملSynthesis of thiophene and N-substituted thieno[3,2-d] pyrimidine derivatives as potent antitumor and antibacterial agents.
A novel series of carbamothioylamino-benzene-sulfonamide-thiophene-carboxylates 4a-c and thieno[3,2-d]pyrimidin-2-yl-amino-benzene-sulfonamides 5a-c were synthesized in a series of synthetic steps and were used as key intermediates for the synthesis of thienotriazolopyrimidine-benzene-sulfonamide derivatives 6a-c and 7a-c. Thieno[3,2-d]pyrimidinones (8 and 9) were also prepared. Compound 9 was ...
متن کاملSynthesis of 2,2′-(1,4-Phenylene)bis-3,4-dihydro-2H-1,3-thiazin-4-ones and their Facile Recyclization to 2,2′-(1,4-Phenylene)bis(pyrimidin-4-one) and/or 2,2′-(1,4-Phenylene)-bis-(thieno[2,3-d]pyrimidin-4(1H)-one) Derivatives
1,3-Thiazines are an important type of heterocycles showing a wide variety of pharmacological properties. Thus, 1,3-thiazine derivatives have recently been reported as cholecystokinin antagonists [1], antimycobacterial agents [2], cannabinoid receptor agonists [3], and inhibitors of NO synthase (NOS) [4], as antibacterial [5], antipyretic [6], anti-inflammatory [6, 7], analgesic [7], antitumor ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2009